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Wednesday, July 29, 2020 | History

3 edition of Tolerance and dopamine depletions after the repeated administration of d-methylamphetamine found in the catalog.

Tolerance and dopamine depletions after the repeated administration of d-methylamphetamine

Kevin T. Finnegan

Tolerance and dopamine depletions after the repeated administration of d-methylamphetamine

by Kevin T. Finnegan

  • 110 Want to read
  • 24 Currently reading

Published .
Written in English


Classifications
LC ClassificationsMicrofilm 80038
The Physical Object
FormatMicroform
Pagination246 p.
Number of Pages246
ID Numbers
Open LibraryOL1249526M
LC Control Number94895073

One hour after administration, MA evokes large depletions of norepinephrine (NE) throughout the brain but somewhat smaller decrements of dopamine (DA) that are restricted to the nigrostriatal :// Specifically, administration of the NMDA receptor antagonist MK‐, even injected after the administration of METH, prevented METH‐induced decreases in activity of complex II–III. Dabbeni‐Sala et al. () demonstrated that incubation with a glutamate receptor agonist causes a selective loss of complex II activity. These effects were

The present study sought to determine whether doses of methamphetamine in the range of those used recreationally by humans produce brain dopamine (DA) neurotoxicity in baboons and to ascertain whether positron emission tomography (PET) imaging with the DA transporter (DAT) ligand [11C]WIN, ([11C]2β-carbomethoxy-3β-(4-fluorophenyl)-tropane) could be used to detect Psychomotor sensitization. Behavioral sensitization is defined as an increase in the locomotor-stimulating effect of a drug after repeated administration (Robinson and Becker, ) and is proposed to be a determinant factor in addictive behavior in rats (Robinson, ; Salamone, ; Robinson and Berridge, ; Stewart, , , ) and in humans (Newlin and Thomson, ; Hunt

  Long-lasting depletions of striatal DA and loss of DA uptake sites following repeated administration of methamphetamine. Brain Res ; – Crossref, Medline, Google Scholar 19 O'Dell SJ, Weihmuller FB, Marshall JF: Methamphetamine-induced dopamine overflow and injury to striatal dopamine terminals: attenuation by dopamine D1 or INTRODUCTION. The United Nations Office on Drugs and Crime estimated that tonnes of methamphetamine was synthesized in 1, which is equivalent to billion ‐mg doses of the phetamine is the second most popular illicit drug world‐wide, with an annual global prevalence estimated at %.


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Tolerance and dopamine depletions after the repeated administration of d-methylamphetamine by Kevin T. Finnegan Download PDF EPUB FB2

The long-term neurochemical and behavioral effects of repeated d-methylamphetamine (d-MA) administration were investigated using four male rhesus monkeys trained to lever-press for food on a DRL s schedule of reinforcement. Dose-response curves for d-MA (– mg/kg), apomorphine (– mg/kg), and haloperidol (– mg/kg) on responding showed that repeated d-MA   Tolerance to MA, increased sensitivity to HAL and no consistent sensitivity change to APO were observed when dose-response functions were redetermined starting 1 month after the repeated MA administration.

One month after these determinations were completed, the brains of the monkeys were analyzed for changes in ://   The effects of prolonged exposure to high doses of stimulants on stimulant self-administration in rhesus monkeys have not been established.

In the present experiment, rates of methamphetamine self-administration as well as the effects of methamphetamine on food-maintained responding were determined before and after a regimen of repeated methamphetamine ://   Pharmacology Biochemistry & Behavior, Vol.

33, pp. Pergamon Press plc, Printed in the U.S.A. /89 $ Long-Term Central 5-HT Depletions Resulting From Repeated Administration of MDMA Enhances the Effects of Single Administration of MDMA on Schedule-Controlled Behavior of Rats ABBY A.

LI, GERARD J. MAREK,2 GEORGETTA VOSMER AND LEWIS S. The neurochemical evidence of methamphetamine (MA)-induced toxicity to dopaminergic nerve terminals is well documented; however, the functional consequences are not clearly defined.

The present study was designed to investigate whether MA-induced dopamine depletions affect locomotor activity, stereotypic behavior, and/or extracellular dopamine concentrations in the ://   Excitotoxic striatal lesions protect against subsequent methamphetamine-induced dopamine depletions.

Pharmacol. Exp. Ther. ; – Ricaurte GA, Schuster CR, Seiden LS. Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study.

Brain Res. ; –   Subchronic d-amphetamine administration ( mg/kg×4, n=8) caused a marked gradual increase in the extracellular levels of glutamate and taurine up to –% and –% of controls, respectively (Fig.

3A and D) and a moderate increase in the aspartate and alanine levels up to –% and –%, respectively (Fig. 3B and C).The effect was already discernible in the case of   Amphetamine is a neurotoxic psychostimulant that causes dopamine depletion and neuronal death in the rodent striatum.

In the present study, we sought to determine if toxic doses of the drug can also induce pathological changes in the mouse olfactory bulb. DOPAMINE TISSUE LEVELS 12 10 8 4 2 0 NA/OT CAUD SEPT 08" 06 04 02 00 F,g 3 Norepmephrme, serotonm and dopamme ttssue levels 12 weeks after treatment with 50 mg/kg methamphetamme or sahne (3 times with 8-h intervals between injections) * D,fferent from sahne- treated controls (P Tolerance-like effects were seen with chronic (mixed results) and mg/kg METH in the absence of dopamine or serotonin depletions measured 2 weeks after the completion of treatment.

After mg/kg METH, variations in ambient temperature resulted in an early flexible change in core temperature (phase 1) (hyperthermia at 28° and Administration of fenfluramine to rats twice daily for 4 days produces long-lasting depletions of serotonin and results in tolerance to both anorectic and neurochemical effects of acute fenfluramine.

On the other hand, a 4 day regimen of MDMA enhances the effects of acute MDMA on a DRL schedule of reinforcement as well as morphine :// Tolerance to the anorectic properties of fenfluramine develops rapidly and long-lasting depletions of brain 5-HT have been reported to occur after repeated administration.

It is possible that Page 1 of 2 - Dopamine receptors cannot be restored after amphetamine use. - posted in Brain Health: I was just reading this article about a student who killed himself after an Adderall addiction, and I saw this quote from a licensed clinical social worker and addiction specialist: It tricks the brain that it doesnt need to make dopamine, and dopamine is the only chemical in the brain that effects of repeated methylamphetamine administration on dopa- mine and serotonin neurons in the rat brain: a regional study, Brain Research, () Nakayama M., Loyama T.

and Yamashita I. () Long-lasting decrease in dopamine uptake sites following repeated administration of methamphetamine in the rat striatum. Brain Res. – CrossRef Google Scholar Drug addiction and dopamine neurotransmission in humans. Abuse of psychoactive substances can lead to drug addiction, a maladaptive behavioral pattern of drug use that is often accompanied by drug tolerance and withdrawal symptoms and causes impairment, distress, and the habitual intake of the drug regardless of the devastating consequences (Diagnostic and Statistical Manual of Mental Ricaurte GA, Schuster CR, Seiden LS ().

Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat Previous studies indicate that the repeated administration of D-methylamphetamine (MA) produces a long-lasting depletion of dopamine (DA), norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5 Amphetamine (AMPH)-induced psychosis is most frequently associated with a chronic high-dose “binge” or “run” pattern of stimulant abuse, generally preceded by a period of gradually escalating doses of the drug.

We showed previously that animals subjected to such a regimen of AMPH administration developed, over multiple daily binges, a unique pattern of behavioral response that included Download Citation | Neurotoxicity of 3, 4-methylenedioxy methamphetamine | Aim: To explore the neurotoxicity and glial fibriliary acidic protein (GFAP) expression of experimental rats induced by 3.

It has been suggested that methamphetamine (METH)‐induced neurotoxicity requires the activation of both dopamine (DA) and glutamate (GLU) systems. To investigate the possibility that METH‐induced increases in extracellular GLU, as measured by in vivo microdialysis (Nash and Yamamoto () Brain Res., –), arise from neuronal stores, postembedding immunogold electron microscopy   Animal studies have shown that repeated administration of amphetamine-like stimulants results in an altered response profile, one prominent feature of which is behavioral sensitization (for review, see Segal et al.,Robinson and Becker, ; Kalivas et al., ; Segal and Kuczenski, ).It has been suggested that this progressive enhancement in responsiveness may be implicated Search the history of over billion web pages on the ://